blood clot, estrogen-associated

blood clot, estrogen-associated A blood clot associated with estrogen therapy. Blood clots are occasional but serious side effects of estrogen therapy. They occur most frequently with high doses of estrogen. Cigarette smokers on estrogen therapy are at a higher risk for blood clots than nonsmokers are. Therefore, patients requiring estrogen therapy are strongly encouraged to quit smoking. See also estrogen; estrogen replacement therapy.