cerebrum

ceruloplasmin deficiency A genetic disorder that is due to a lack of ceruloplasmin, a protein that is involved in iron transport. The absence of ceruloplasmin leads to the abnormal deposition of iron in the pancreas (causing diabetes), liver (causing cirrhosis), retina (damaging vision), and brain (causing dementia and Parkinson’s disease). Aggressive treatment with deferoxamine, a chelating agent that takes up iron, halts the progression of these complications. Also known as aceruloplasminemia.