Morquio syndrome

Morquio syndrome A form of mucopolysaccharidosis that is characterized by an inability to break down keratan sulfate, which leads to abnormal accumulation of keratan sulfate in muscle and skeletal tissues. This in turn can lead to abnormalities of the skeleton, muscles, skin, teeth, and muscular organs. Diagnosis is made by examining leukocytes and cultured skin fibroblasts or by checking urine for high levels of keratan sulfate. There is currently no treatment for Morquio syndrome, but physical therapy, medication, and sometimes surgery can reduce discomfort and enhance the patient’s ability to move. Morquio syndrome is inherited in an autosomal recessive manner. Also known as mucopolysaccharidosis type IV (MPS4). See also mucopolysaccharidosis.