rickets, hypophosphatemic

rickets, hypophosphatemic A rare genetic form of rickets that is characterized by low blood phosphate level (hypophosphatemia), defective intestinal absorption of phosphate, and unresponsiveness to vitamin D. The basic problem in hypophosphatemic rickets is decreased resorption of phosphate by the tubules in the kidney. Females typically have less severe disease than males. The condition is inherited in an X-linked dominant manner. Also known as vitamin D–resistant rickets. See also rickets.