Zollinger-Ellison syndrome

Zollinger-Ellison syndrome A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine. Gastrinomas resulting in the Zollinger-Ellison syndrome may also occur in the stomach, duodenum, spleen, and lymph nodes. Treatment can include the use of H2 antagonist medications, proton pump inhibitors, or surgical removal of the tumor.