osteoclastoma A tumor of bone characterized by massive destruction of the end (epiphysis) of a long bone. The site most commonly struck by this tumor is the knee — the far end of the femur and the near end of the tibia. The tumor is often coated by new bony growth and may grow aggressively….
osteocyte A bone cell.
osteodystrophy A bone disorder that adversely affects bone growth and development. Osteodystrophy is most commonly caused by chronic kidney failure, but it can be inherited, such as in Albright hereditary osteodystrophy. Osteodystrophy can require treatment with vitamin D. See also osteodystrophy, renal.
osteodystrophy, renal A bone disorder that adversely affects bone growth and is caused by chronic kidney failure (renal disease). Osteodystrophy can require treatment with vitamin D. Also known as kidney osteodystrophy.
osteogenesis The production of bone.
osteogenesis imperfecta A group of inherited connective tissue diseases, all of which result from mutations that affect collagen in connective tissue in the body, and all of which result in fragile bones. The best known types of osteogenesis imperfecta are types I and II. Also known as brittle bone disease.
osteogenesis imperfecta congenita See osteogenesis imperfecta type II.
osteogenesis imperfecta tarda See osteogenesis imperfecta type I.
osteogenesis imperfecta type I A type of osteogenesis imperfecta that features bone fragility and blue sclerae (bluish whites of the eyes). Osteogenesis imperfecta type I is the classic, mild form of brittle bone disease. It is inherited as an autosomal dominant trait. It is characterized by fragile bones that are predisposed to fracture, the onset…
osteogenesis imperfecta type II A type of osteogenesis imperfecta that features very severe bone fragility. Osteogenesis imperfecta type II is the lethal form of brittle bone disease. The disease is characterized by short-limb dwarfism, thin skin, a soft skull, unusually large fontanels (soft spots), blue sclerae (bluish whites of the eyes), small nose, low nasal…
osteogenesis imperfecta with blue sclerae See osteogenesis imperfecta type II.
osteogenic sarcoma See osteosarcoma.