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GM2-gangliosidosis
GM2-gangliosidosis One of a group of genetic lipid storage disorders that affect the brain. The main types of GM2 gangliosidoses are Tay-Sachs disease and its variants (due to hexosaminidase A deficiency) and Sandhoff disease and its variants (due to hexosaminidase B deficiency). See also Sandhoff disease; Tay-Sachs disease.