Letterer-Siwe disease

Letterer-Siwe disease A form of Langerhans cell histiocytosis starting in infancy that involves proliferation of histiocytes in multiple organs such as the skin, bones, and other organs. Symptoms include rash, swollen glands, enlargement of the liver and spleen, liver disease, anemia, and lytic lesions of the bones. Letterer-Siwe disease is the most severe form of Langerhans cell histiocytosis and has a high mortality rate.