methotrexate

methotrexate An immune-suppressing drug (brand names: Rheumatrex, Trexall) that is used to treat rheumatoid arthritis, severe psoriasis, reactive arthritis, and severe asthma. In high doses it is also used as a part of cancer chemotherapy programs. Methotrexate is an effective but potentially dangerous medication. People taking methotrexate must have their lung, liver, and kidney function monitored regularly, and they need blood testing to be done frequently as well. Methotrexate interacts dangerously, and potentially fatally, with many other medications, including prescription and over-thecounter nonsteroidal anti-inflammatory drugs, even aspirin and ibuprofen. Folic acid supplements are sometimes used to counteract side effects of methotrexate. Methotrexate should be taken on an empty stomach.