protein C deficiency

protein C deficiency A deficiency of the anticoagulant protein C, that results in thrombotic (clotting) disease and excess platelets, and recurrent inflammation of the vein that occurs when a clot forms (thrombophlebitis). The clot can break loose and travel through the bloodstream, causing damage to organs including stroke and heart attack. Protein C deficiency is due to one of numerous mutations in the protein C gene on chromosome 2.