familial Mediterranean fever

familial Mediterranean fever A rare genetic disorder that is characterized by recurrent attacks of inflammation, with fever and pain in the abdomen, chest, and/or joints. Abbreviated FMF. FMF attacks typically last for 12 to 72 hours. The symptoms may differ from patient to patient, even in the same family. In some cases, protein deposits, called amyloid, can accumulate in tissues (amyloidosis). When this injures the kidneys it can lead to kidney failure. Colchicine prevents the attacks of pain and the deposition of amyloid. FMF is inherited as an autosomal recessive trait. Molecular testing for mutations in the MEFV gene (on chromosome 16) confirms the diagnosis. Molecular genetic testing can also detect carriers and the prenatal presence of FMF. Also known as recurrent polyserositis.