anencephaly

anencephaly Absence of the cranial vault and of most or all of the cerebral hemispheres of the brain, a lethal malformation. Anencephaly is due to imperfect development of the neural tube, the structure that gives rise to the central nervous system, during very early pregnancy. The upper end of the neural tube fails to close….

anemia, sickle cell

anemia, sickle cell A genetic blood disorder caused by the presence of an abnormal, sickleshaped form of hemoglobin. These hemoglobin molecules tend to aggregate after unloading oxygen, forming long, rod-like structures that force the red cells to assume a sickle shape. Unlike normal red cells, which are usually smooth and malleable, the sickle red cells…

anemia, pernicious

anemia, pernicious Low red blood cell count caused by inadequate vitamin B12. Abbreviated PA. Patients with PA do not produce intrinsic factor (IF), a substance that allows the body to absorb vitamin B12 from foods. The resulting inadequacy of vitamin B12 hampers the production of red blood cells. PA can be treated by injection of…