thrombotic thrombocytopenic purpura

thrombotic thrombocytopenic purpura A life-threatening disease that involves embolism and thrombosis (plugging) of the small blood vessels in the brain and elsewhere in the body. Abbreviated TTP. TTP is characterized by the presence of platelet microthrombi (tiny traveling clots composed of platelets, the clotting cells in the blood), thrombocytopenia (lack of platelets), hemolytic anemia (from the breakup of red blood cells), fever, kidney abnormalities, and nervous system abnormalities such as aphasia, blindness, and convulsions. TTP can be triggered by many drugs. Treatment may include plasma exchange with fresh or frozen plasma, dialysis, and corticosteroids.